Adjunctive lithium treatment in the prevention of suicidal behaviour in depressive disorders: a randomised, placebo-controlled, 1-year trial

Autor:	Bernd Ahrens, Arnim Quante, Birgit Kilb, Erik Lauterbach, Thomas Bronisch, Thorsten Meyer, Ute Lewitzka, Kneginja Richter, Werner Felber, Andreas Broocks, Barbara Hawellek, Bruno Müller-Oerlinghausen, Fritz Hohagen
Rok vydání:	2008
Předmět:	Adult Male Suicide Prevention medicine.medical_specialty Lithium (medication) Poison control Suicide Attempted Comorbidity Kaplan-Meier Estimate Personality Assessment Placebo Suicide prevention law.invention Adjustment Disorders Lithium Carbonate Randomized controlled trial law Internal medicine Secondary Prevention medicine Humans Affective spectrum Psychiatry Depressive Disorder Major Suicide attempt business.industry Hazard ratio Middle Aged medicine.disease Antidepressive Agents Suicide Psychiatry and Mental health Cross-Sectional Studies Female Dysthymic Disorder business Follow-Up Studies medicine.drug
Zdroj:	Acta Psychiatrica Scandinavica. 118:469-479
ISSN:	1600-0447 0001-690X
DOI:	10.1111/j.1600-0447.2008.01266.x
Popis:	Objective: Evidence based on controlled studies is still limited for treatment strategies that prevent recurrence of suicide attempts. Findings from observational as well as meta-analytic studies strongly suggest that lithium may have suicide-protective properties. Method: Patients with a recent suicide attempt in the context of an affective spectrum disorder (n = 167) were treated with either lithium or placebo during a 12-month period. Results: Survival analysis showed no significant difference of suicidal acts between lithium and placebo-treated individuals (adjusted hazard ratio 0.517; 95% CI 0.18–1.43). However, post hoc analysis revealed that all completed suicides had occurred in the placebo group accounting for a significant difference in incidence rates (P = 0.049). Conclusion: Results indicate that lithium treatment might be effective in reducing the risk of completed suicide in adult patients with affective disorders. Our findings contribute to the growing body of evidence suggesting a specific antisuicidal effect of lithium.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36345e4ecf4c4b8a14be5cc7686b9de6 https://doi.org/10.1111/j.1600-0447.2008.01266.x Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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