Plasma clozapine levels and clinical response in treatment-refractory Chinese schizophrenic patients
| Autor: | Alfert Wai-kiu Tsang, Henry Hon-kee Cheung, Kai-tai Chan, Wing-Kit Choi, Roger Man Kin Ng, Jessica O. Y. Wong, Judy Po Shan Lai, Tony W. L. Mak, Shung-pun Leung |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male China medicine.medical_specialty Psychosis Time Factors Adolescent Side effect Population Sensitivity and Specificity Gastroenterology Statistics Nonparametric Internal medicine Blood plasma Electrochemistry medicine Humans Drug Interactions education Clozapine Chromatography High Pressure Liquid Biological Psychiatry Aged Pharmacology education.field_of_study Valproic Acid Antagonist Plasma levels Middle Aged medicine.disease ROC Curve Schizophrenia Anesthesia Anticonvulsants Female Psychology Antipsychotic Agents medicine.drug |
| Zdroj: | Progress in Neuro-Psychopharmacology and Biological Psychiatry. 30:251-264 |
| ISSN: | 0278-5846 |
| DOI: | 10.1016/j.pnpbp.2005.10.008 |
| Popis: | Purpose To evaluate clinical efficacy of clozapine in relation with its plasma level in a group of Chinese patients with treatment-resistant schizophrenia. In addition, the relationship between plasma level and side effects were examined. Method Fifty-one patients with treatment-resistant schizophrenia were put on a fixed dose of clozapine at 300 mg/day for 6 weeks. Non-responders to week 6 received 500 mg/day in subsequent 6 weeks. Responders to week 6 continued to receive 300 mg/day. Clozapine plasma levels were checked at weeks 6 and 12. Findings No association was found between clozapine plasma level, response and side effects. Sodium valproate was found to elevate clozapine plasma level while lowering norclozapine/clozapine ratio. Conclusion Clozapine plasma level was not found to be associated with response and side effect in Chinese treatment-resistant schizophrenic patients. Various explanations were postulated for the lack of relationship observed between clozapine plasma level and response in this population. |
| Databáze: | OpenAIRE |
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