Sudden increase in virulence in a strain of Plasmodium berghei yoelii
| Autor: | D. Walliker, Meir Yoeli, Richard Carter, B. J. Hargreaves |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Erythrocytes
Plasmodium berghei 030231 tropical medicine Electrophoresis Starch Gel Virulence Drug resistance Virus Microbiology 03 medical and health sciences Mice 0302 clinical medicine Transformation Genetic 030225 pediatrics parasitic diseases Anopheles Freezing Gametocyte Parasite hosting Animals Anopheles stephensi Recombination Genetic Strain (chemistry) biology biology.organism_classification Virology Malaria Infectious Diseases Parasitology |
| Zdroj: | Annals of tropical medicine and parasitology. 69(2) |
| ISSN: | 0003-4983 |
| Popis: | The mild and chronic 17X strain of Plasmodium berghei yoelii showed a sudden increase in virulence following a period of 110 days in the deep freeze. The enhanced virulence was seen in a very high and early parasite peak in the blood and a 100% mortality of all infected mice. The exalted virulence remained unaltered following a number of blood transfers of the strain and after four cyclical transmissions through Anopheles stephensi. Enzyme pattern studies revealed that the virulent strain possessed the enzyme types GPI-1 and 6 PGD-4,-both characteristic for strain 17X of P.b. yoelii. Studies carried out to investigate the possibility of a concomitant viral infection transferred by blood passage, which could have been responsible for the enhanced virulence and mortality in the infected mice, showed no presence of any detectable virus in the blood of the P.b. yoelii infected mice. It is suggested that virulence may provide a marker in genetic work of rodent plasmodia and be included in association with enzyme and drug resistance markers. |
| Databáze: | OpenAIRE |
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