Defects and DNA replication
| Autor: | Michel G. Gauthier, John Herrick, John Bechhoefer |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
DNA Replication
DNA Repair DNA repair DNA damage DNA biosynthesis DNA replication General Physics and Astronomy Nanotechnology DNA Origin of replication Models Biological Formalism (philosophy of mathematics) chemistry.chemical_compound Kinetics Dna genetics chemistry Biophysics Animals Humans DNA Damage |
| Zdroj: | Physical review letters. 104(21) |
| ISSN: | 1079-7114 |
| Popis: | We introduce a rate-equation formalism to study DNA replication kinetics in the presence of defects resulting from DNA damage and find a crossover between two regimes: a normal regime, where the influence of defects is local, and an initiation-limited regime. In the latter, defects have a global impact on replication, whose progress is set by the rate at which origins of replication are activated, or initiated. Normal, healthy cells have defect densities in the normal regime. Our model can explain an observed correlation between interorigin separation and rate of DNA replication. |
| Databáze: | OpenAIRE |
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