Neurobehavioral function and low-level metal exposure in adolescents
| Autor: | Liesbeth Bruckers, Isabelle Sioen, Griet Vermier, Elly Den Hond, Tim S. Nawrot, Willy Baeyens, Vera Nelen, Mineke K. Viaene, Nicolas Van Larebeke, Jan Vrijens, Michal Kicinski, Greet Schoeters |
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| Přispěvatelé: | Chemistry, Vriendenkring VUB, Analytical, Environmental & Geo-Chemistry |
| Rok vydání: | 2015 |
| Předmět: |
Male
Passive smoking Adolescent media_common.quotation_subject Short-term memory Physiology Poison control Urine 010501 environmental sciences medicine.disease_cause 01 natural sciences Toxicology 03 medical and health sciences Cognition 0302 clinical medicine Injury prevention Humans Medicine Attention Methyl hg Menstrual cycle 0105 earth and related environmental sciences media_common business.industry Public Health Environmental and Occupational Health Neurotoxicity Environmental Exposure medicine.disease 3. Good health Memory Short-Term Lead Environmental Pollutants Female Human medicine business Copper 030217 neurology & neurosurgery |
| Zdroj: | International journal of hygiene and environmental health International Journal of Hygiene and Environmental Health |
| ISSN: | 1438-4639 |
| DOI: | 10.1016/j.ijheh.2014.09.002 |
| Popis: | An excessive metal exposure is harmful to the brain. However, many aspects of metal neurotoxicity remain unclear including the magnitude of the low-level exposure effects and the level of exposure that can be assumed safe. The aim of our study was to investigate the association between a low-level metal exposure and three neurobehavioral domains (sustained attention, short-term memory, and manual motor speed). We measured Cd, Cu, Mn, Pb, and Tl in blood, Cd, Ni, and toxicologically relevant As in urine and methyl Hg in hair in 606 adolescents between 13.6 and 17 years of age. A two-fold increase in blood Cu was associated with a 0.37 standard deviations decrease in sustained attention (95% CI: -0.67 to -0.07, p = 0.02) and 0.39 standard deviations decrease in short-term memory (95% CI: -0.70 to -0.07, p = 0.02), accounting for gender, age, smoking, passive smoking, household income per capita, occupation of the parents, and education level of the mother. None of the other metals was significantly associated with the neurobehavioral domains that were measured. The observed associations between blood Cu and neurobehavioral performance are in line with recent studies in elderly. However, the relevance of our results for public health remains to be elucidated. (C) 2014 Elsevier GmbH. All rights reserved. |
| Databáze: | OpenAIRE |
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