Chemical, antioxidant and cytotoxic profile of hydroalcoholic extracts of plants from Southern Brazil and their activity against pathogenic fungi isolated from dogs and cats with sensitivity and resistance to conventional antifungals
| Autor: | Fábio Clasen Chaves, Luciana Laitano Dias de Castro, Stefanie Bressan Waller, Jessica Fernanda Hoffmann, Isabel Martins Madrid, Karina Affedlt Guterres, Claudia Giordani, Caroline Bohnen de Matos, Marlete Brum Cleff, Renata Osório de Faria |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
food.ingredient
Antioxidant Schinus Antifungal Agents medicine.medical_treatment Persicaria hydropiperoides Persicaria Plant Science Microbial Sensitivity Tests Biology Cat Diseases Biochemistry Antioxidants Analytical Chemistry food Dogs medicine Cytotoxic T cell Animals Dog Diseases CATS Traditional medicine Plant Extracts Organic Chemistry Eugenia uniflora biology.organism_classification Malassezia pachydermatis Cats Brazil |
| Zdroj: | Natural product research. 36(12) |
| ISSN: | 1478-6427 |
| Popis: | We aimed to evaluate the chemical, antioxidant, cytotoxic, and antifungal activities of hydroalcoholic extracts of native plants from Southern Brazil: Schinus terebinthifolia (SCH), Persicaria hydropiperoides (PER), Eugenia uniflora (EUG) and Equisetum hyemale (EQU). Ethyl gallate, quercetin, and quinic acid were prevalent compounds identified by LC-MS. For total phenolic/flavonoid contents and the antioxidant potential against ABTS/DPPH radicals, the ascending order was EQU 75%) at concentrations up to 12.5 mg/mL (MTT assay). By M38-A2/M27-A3 (CLSI) against 68 clinical isolates of animals and strains of Malassezia pachydermatis, Sporothrix brasiliensis, Microsporum canis, Microsporum gypseum and Trichophyton mentagrophytes, all extracts (MIC/MFC ≤3.13–100 mg/mL) were active, except EUG. SCH inhibited and killed S. brasiliensis (MIC/MFC50/90 3.12–12.5 mg/mL) and dermatophytes (MIC/MFC 6.25–25 mg/mL) resistant to ketoconazole and itraconazole. These findings support the promising use of the selected plant extracts as antifungal agents. |
| Databáze: | OpenAIRE |
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