Tryptophol Induces Death Receptor (DR) 5-Mediated Apoptosis in U937 Cells
| Autor: | Hiroshi Akutagawa, Yue-Qin Tang, Kenji Kida, Shigeru Morimura, Shyuichiro Inagaki |
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| Rok vydání: | 2007 |
| Předmět: |
Indoles
Apoptosis Biology GPI-Linked Proteins Applied Microbiology and Biotechnology Biochemistry Analytical Chemistry chemistry.chemical_compound Receptors Tumor Necrosis Factor Member 10c Tryptophol Humans Lymphocytes Viability assay Receptor Molecular Biology Caspase 8 U937 cell Caspase 3 Organic Chemistry U937 Cells General Medicine Transfection Peripheral blood Cell biology Receptors TNF-Related Apoptosis-Inducing Ligand Tumor Necrosis Factor Decoy Receptors chemistry Tumor necrosis factor alpha Biotechnology |
| Zdroj: | Bioscience, Biotechnology, and Biochemistry. 71:2065-2068 |
| ISSN: | 1347-6947 0916-8451 |
| DOI: | 10.1271/bbb.70084 |
| Popis: | Tryptophol is a natural component isolated from vinegar produced from the boiled extract of black soybean. We have reported that tryptophol induces apoptosis in U937 cells via activation of caspase-8 followed by caspase-3. Tryptophol, however, did not affect human peripheral blood lymphocytes (PBL). In this study, we found that tryptophol enhances formation of a death-inducing signaling complex including death receptor (DR) 5. Cell viability and induction of apoptosis by tryptophol was reduced by transfection with decoy receptor (DcR) 1. These results indicate that tryptophol induces apoptosis through DR5 and that the resistance of PBL to tryptophol-induced apoptosis might be due to competition from DcR1. |
| Databáze: | OpenAIRE |
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