CD10 AND CD34 expression in childhood acute lymphoblastic leukemia in Morocco: clinical relevance and outcome
| Autor: | Hicham Bellaoui, Abdelaziz Benjouad, M. Khattab, Nadia Bouzid, Youssef Bakri, Nadia Dakka |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Adolescent T-Lymphocytes CD34 Antigens CD34 Kaplan-Meier Estimate Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Gastroenterology Antigen immune system diseases hemic and lymphatic diseases Internal medicine Precursor B-Cell Lymphoblastic Leukemia-Lymphoma medicine Biomarkers Tumor Humans Clinical significance Child neoplasms Childhood Acute Lymphoblastic Leukemia Survival rate Survival analysis B-Lymphocytes business.industry Follow up studies Infant Hematology Survival Rate Morocco Oncology Child Preschool Pediatrics Perinatology and Child Health Immunology Acute lymphoblastic leukemias Female Neprilysin business Follow-Up Studies |
| Zdroj: | Pediatric hematology and oncology. 26(4) |
| ISSN: | 1521-0669 |
| Popis: | CD10 and CD34 expression in 86 Moroccan children with acute lymphoblastic leukemias (ALL) and the relevance to prognosis, diagnosis, and outcome during a 5-year follow-up were examined. At diagnosis, 57% of patients had CD10(+) blasts, while 35% had CD34(+) blasts. The CD10(+) blast frequency was much higher (80%) in B-ALL than in T-ALL (20%). The frequency of CD34(+) blasts was higher in B-ALL (48%) compared to T-ALL (16%). The 5-year survival curves showed that children with CD10(+) B-ALL had a significantly longer survival rate than those with CD10(-), as observed for T-ALL. The survival rate of B-ALL expressing CD34 was higher than that of CD34(-). Thus, CD34 and CD10 expression may have prognostic value and is associated with a better clinical outcome. |
| Databáze: | OpenAIRE |
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