The effect of dilution on plasma coagulation kinetics determined by thrombelastography is dependent on antithrombin activity and mode of activation
| Autor: | William Q. Gurley, Vance G. Nielsen, Ralph T. Lyerly |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Serine Proteinase Inhibitors
medicine.medical_treatment Alpha (ethology) In Vitro Techniques Thrombophilia Antithrombins Plasma Medicine Humans Citrates Saline Blood Coagulation Hemodilution Chromatography business.industry Antithrombin medicine.disease Diatomaceous Earth Elasticity Dilution Thrombelastography Kinetics Anesthesiology and Pain Medicine Coagulation kinetics Blood Preservation Anesthesia business medicine.drug |
| Zdroj: | Anesthesia and analgesia. 99(6) |
| ISSN: | 0003-2999 |
| Popis: | Hemodilution-associated hypercoagulability has been the focus of several investigations because significant morbidity and mortality have been associated with perioperative thrombophilia. Because most investigations implicate imbalances in procoagulant/anticoagulant activity as the etiology of hemodilution-associated hypercoagulability, we determined the effects of dilution on coagulation kinetics and clot strength with thrombelastography (TEG(R)). Control plasma (+/-celite activation) and antithrombin (AT)-deficient ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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