Drosophila Toll links systemic immunity to long-term intestinal function
| Autor: | Magda L. Atilano, Lai Mun Wang, Marcus Glittenberg, Petros Ligoxygakis, Bahuguna S |
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| Rok vydání: | 2018 |
| Předmět: |
0303 health sciences
biology Immune receptor Gut flora biology.organism_classification Cell biology 03 medical and health sciences 0302 clinical medicine Immune system Transcription (biology) RNA interference Toll biology.protein 030217 neurology & neurosurgery 030304 developmental biology Adult stem cell Progenitor |
| DOI: | 10.1101/248138 |
| Popis: | The intestine is an organ where immune and metabolic functions are co-ordinated with tissue renewal via progenitor somatic stem cells (PSSCs). How this is achieved is still unclear. We report that in Drosophila, a generalised infection increased PSSC numbers. This was mimicked by expressing a constitutive form of the immune receptor Toll in PSSCs and blocked when Toll was silenced via RNAi. Without infection, absence of bacterial recognition and downstream Toll signalling resulted in a short lifespan and an age-dependent decrease of PSSCs and gut microbiota. The latter implied a metabolic environment incompatible with the presence of bacteria. Indeed, infection or constitutive Toll signalling in PSSCs triggered 4E-BP transcription in enterocytes, while loss of signalling reduced it. 4E-BP controlled fat levels and sustained the microbiota suggesting that Toll-dependent regulation of 4E-BP was important for long-term gut function. Therefore, the Toll pathway is crucial for responses to both infection and microbiota. |
| Databáze: | OpenAIRE |
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