Reduced prevalence of SARS-CoV-2 infection in ABO blood group O
| Autor: | Keld Homburg, Bitten Aagaard, Henrik Støvring, Kjell Titlestad, Morten Bagge Hansen, Torben Barington, Thure Mors Haunstrup, Mike Bogetofte Barnkob, Rune B. Larsen, Bjarne Kuno Møller, Anton Pottegård |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Blodtype COVID19 Clinical Trials and Observations VON-WILLEBRAND-FACTOR Denmark Coronavirus Infections/blood Pneumonia Viral 030204 cardiovascular system & hematology DISEASE ABO Blood-Group System Danish 03 medical and health sciences Betacoronavirus 0302 clinical medicine Risk Factors Internal medicine ABO blood group system medicine Prevalence Humans Risk factor Pandemics Reference group Retrospective Studies Betacoronavirus/isolation & purification business.industry Pneumonia Viral/blood SARS-CoV-2 COVID-19 Retrospective cohort study Hematology Protective Factors medicine.disease Confidence interval language.human_language Denmark/epidemiology Pneumonia 030104 developmental biology Relative risk language Corona Female ABO Blood-Group System/blood business Coronavirus Infections |
| Zdroj: | Barnkob, M B, Pottegård, A, Støvring, H, Haunstrup, T M, Homburg, K, Larsen, R, Hansen, M B, Titlestad, K, Aagaard, B, Møller, B K & Barington, T 2020, ' Reduced prevalence of SARS-CoV-2 infection in ABO blood group O ', Blood Advances, vol. 4, no. 20, pp. 4990-4993 . https://doi.org/10.1182/BLOODADVANCES.2020002657 Barnkob, M B, Pottegård, A, Støvring, H, Haunstrup, T M, Homburg, K, Larsen, R, Hansen, M B, Titlestad, K, Aagaard, B, Møller, B K & Barington, T 2020, ' Reduced prevalence of SARS-CoV-2 infection in ABO blood group O ', Blood advances, vol. 4, no. 20, pp. 4990-4993 . https://doi.org/10.1182/bloodadvances.2020002657 Blood Adv Barnkob, M B, Pottegård, A, Støvring, H, Haunstrup, T M, Homburg, K, Larsen, R, Hansen, M B, Titlestad, K, Aagaard, B, Møller, B K & Barington, T 2020, ' Reduced prevalence of SARS-CoV-2 infection in ABO blood group O ', Blood advances, vol. 4, no. 20, pp. 4990–4993 . https://doi.org/10.1182/bloodadvances.2020002657 |
| DOI: | 10.1182/BLOODADVANCES.2020002657 |
| Popis: | Identification of risk factors for contracting and developing serious illness following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is of paramount interest. Here, we performed a retrospective cohort analysis of all Danish individuals tested for SARS-CoV-2 between 27 February 2020 and 30 July 2020, with a known ABO and RhD blood group, to determine the influence of common blood groups on virus susceptibility. Distribution of blood groups was compared with data from nontested individuals. Participants (29% of whom were male) included 473 654 individuals tested for SARS-CoV-2 using real-time polymerase chain reaction (7422 positive and 466 232 negative) and 2 204 742 nontested individuals, accounting for ∼38% of the total Danish population. Hospitalization and death from COVID-19, age, cardiovascular comorbidities, and job status were also collected for confirmed infected cases. ABO blood groups varied significantly between patients and the reference group, with only 38.41% (95% confidence interval [CI], 37.30-39.50) of the patients belonging to blood group O compared with 41.70% (95% CI, 41.60-41.80) in the controls, corresponding to a relative risk of 0.87 (95% CI, 0.83-0.91) for acquiring COVID-19. This study identifies ABO blood group as a risk factor for SARS-CoV-2 infection but not for hospitalization or death from COVID-19. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|