The progress of chemokines and chemokine receptors in autism spectrum disorders
| Autor: | Hong-Yun Wang, Li-Yuan Cui, Junrui Ye, Nai-Hong Chen, Shifeng Chu |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Chemokine genetic structures Autism Spectrum Disorder Inflammation behavioral disciplines and activities 03 medical and health sciences Chemokine receptor 0302 clinical medicine Drug Discovery mental disorders medicine Humans Clinical treatment Neuroinflammation biology Drug discovery business.industry General Neuroscience Cell migration medicine.disease 030104 developmental biology biology.protein Autism Receptors Chemokine Chemokines medicine.symptom business Neuroscience 030217 neurology & neurosurgery Protein Binding |
| Zdroj: | Brain Research Bulletin. 174:268-280 |
| ISSN: | 0361-9230 |
| DOI: | 10.1016/j.brainresbull.2021.05.024 |
| Popis: | Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders and the main symptoms of ASD are impairments in social communication and abnormal behavioral patterns. Studies have shown that immune dysfunction and neuroinflammation play a key role in ASD patients and experimental models. Chemokines are groups of small proteins that regulate cell migration and mediate inflammation responses via binding to chemokine receptors. Thus, chemokines/chemokine receptors may be involved in neurodevelopmental disorders and associated with ASD. In this review, we summarize the research progress of chemokine aberrations in ASD and also review the recent progress of clinical treatment of ASD and pharmacological research related to chemokines/chemokine receptors. This review highlights the possible connection between chemokines/chemokine receptors and ASD, and provides novel potential targets for drug discovery of ASD. |
| Databáze: | OpenAIRE |
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