Transdermal 17-β estradiol replacement therapy reduces megakaryocyte GPVI expression
| Autor: | Hongquan Geng, Hui Zhang, Xing-Hong Leng, Wei Zhang, Bernhard Nieswandt, Paul F. Bray |
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| Rok vydání: | 2008 |
| Předmět: |
Agonist
medicine.medical_specialty medicine.drug_class Platelet Membrane Glycoproteins Administration Cutaneous Mice Megakaryocyte Internal medicine medicine Animals Platelet Transdermal Estradiol business.industry Estrogen Replacement Therapy Fibrinogen binding Hematology Mice Inbred C57BL medicine.anatomical_structure Endocrinology Estrogen Ovariectomized rat Female GPVI business Megakaryocytes |
| Zdroj: | Thrombosis Research. 123:93-99 |
| ISSN: | 0049-3848 |
| Popis: | The platelet-collagen interaction is a critical early event in arterial thrombus formation, and platelet GPVI is the major activating receptor for collagen. We have previously used a mouse model to demonstrate that the estrogen effects on platelets depend upon the agonist, estrogen formulation and route of administration. In the current study we used a model of transdermal estradiol (E2) administration to ovariectomized mice to address the potential inhibitory effects of E2 on platelet GPVI. Platelet GPVI expression was reduced after transdermal E2 replacement therapy (p |
| Databáze: | OpenAIRE |
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