Safety Profile of Caesalpinia spinosa Aqueous Extract Tested in Oreochromis niloticus Toward Its Application in Dermocosmetics
| Autor: | Monica Arqueros, Linda Sánchez-Tuesta, Jan Pier Crespo, Angelita Cabrera, Zulita Prieto, Carmen Ayala, Renata Miliani Martinez, Nataly Reategui-Pinedo, André Rolim Baby, David Salirrosas |
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| Rok vydání: | 2021 |
| Předmět: |
safety
Caesalpinia spinosa Traditional medicine biology Chemistry natural cosmetic Oreochromis niloticus CAESALPINIACEAE biology.organism_classification medicine.disease_cause HB1-3840 Oreochromis herbal extract In vivo Polyphenol Toxicity medicine Economic theory. Demography Caesalpinia Chronic toxicity Genotoxicity Ex vivo |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Frontiers in Sustainability, Vol 2 (2021) |
| ISSN: | 2673-4524 |
| Popis: | Herbal extracts have been widely used in dermocosmetics as a source of biomolecules and also as a natural claim. Fruits from Caesalpinia spinosa show great potential for their polyphenolic content, preservative, and film-forming features, as previously reported in specialized literature; however, the toxicity requires investigation. We explored Oreochromis niloticus (tilapia) in larval, alevins, and juvenile stages to evaluate the ex vivo and in vivo genotoxicity and in vivo acute and chronic toxicity of C. spinosa aqueous extract in different concentrations. Cytotoxicity, animal behavior, morphological deformities, and DNA damage were evaluated. Our results showed genotoxic effect in ex vivo tests, but no DNA damage in in vivo erythrocytes. We suggest a mechanism of cell permeability involved in the toxicity of C. spinosa aqueous extract. Internal validation showed the feasibility of O. niloticus applied for toxicity evaluation. Further studies could contribute for better understanding the uses and safety of C. spinosa in cosmetics and topical pharmaceutical products. |
| Databáze: | OpenAIRE |
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