Combined oral contraceptives and gonadotropin releasing hormone agonistic analogs in polycystic ovary syndrome: clinical and experimental studies
| Autor: | A. Lytras, V. Syriou, G. Tolis, I. Halikias |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Infertility
medicine.medical_specialty medicine.drug_class Ovary Gonadotropin-releasing hormone Gonadotropin-Releasing Hormone Internal medicine medicine Endocrine system Animals Humans Pharmacology (medical) Growth Substances hirsutism business.industry Obstetrics and Gynecology Estrogens Luteinizing Hormone medicine.disease Polycystic ovary Rats Contraceptives Oral Combined Disease Models Animal medicine.anatomical_structure Endocrinology Reproductive Medicine Cytokines Drug Therapy Combination Female Gonadotropin Follicle Stimulating Hormone business Hormone Polycystic Ovary Syndrome |
| Zdroj: | The European journal of contraceptionreproductive health care : the official journal of the European Society of Contraception. 2(4) |
| ISSN: | 1362-5187 |
| Popis: | Polycystic ovary syndrome is a common endocrine disorder, presenting with menstrual irregularities, hirsutism, obesity, infertility and abnormal ovarian morphology. In addition, polycystic ovary syndrome is associated with a self-perpetuating imbalance involving the endocrine system and metabolic pathways, in which carbohydrates, lipids and growth factors are involved. Because of its chronicity, it is considered to be a substantial risk factor for atherogenesis and hormone-dependent neoplasia. The etiology and pathophysiology of the syndrome remain elusive. However, during the last decade, several clues have emerged from human and animal studies that may have significant repercussions in the treatment of polycystic ovary syndrome. Therapeutic maneuvers should be directed towards the dominant abnormalities present in individual patients with polycystic ovary syndrome. Gonadotropin releasing hormone (GnRH) agonists can directly affect the gonadotropin generator and secondary downstream derangements, whereas combined oral contraceptives (COCs) can modify hypothalamic as well as peripheral abnormalities. In view of the fact that GnRH agonistic analogs (GnRH-a) will induce hypoestrogenemia and its sequelae, the add-back strategy of estrogenic supplementation is recommended for preventive reasons and, as it transpires from some studies, for enhancement of GnRH-a effectiveness. |
| Databáze: | OpenAIRE |
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