Effects of Aspirin and Intrauterine Balloon on Endometrial Repair and Reproductive Prognosis in Patients with Severe Intrauterine Adhesion: A Prospective Cohort Study
| Autor: | Yuqing Chen, Yang Huan, Lixiang Liu, Yuanna Luo, Ruili Fang, Minghui Chen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
medicine.medical_specialty Article Subject medicine.drug_class Urology lcsh:Medicine Tissue Adhesions Hysteroscopy Balloon Intrauterine device General Biochemistry Genetics and Molecular Biology Endometrium 03 medical and health sciences 0302 clinical medicine Pregnancy medicine Humans Prospective Studies Prospective cohort study Uterine Balloon Tamponade Postoperative Care Uterine Diseases Wound Healing Aspirin 030219 obstetrics & reproductive medicine General Immunology and Microbiology medicine.diagnostic_test business.industry Reproduction lcsh:R General Medicine Prognosis medicine.disease Menstruation Surgery Estrogen 030220 oncology & carcinogenesis Female business Research Article medicine.drug |
| Zdroj: | BioMed Research International, Vol 2017 (2017) BioMed Research International |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | This study aimed to investigate the effects of estrogen in combination with aspirin and intrauterine balloon on the uterine endometrial repair and reproductive prognosis in patients after surgery for severe intrauterine adhesion (sIUA). We prospectively recruited 114 patients with sIUA. Intrauterine device (IUD) was placed and oral estrogen was administered after surgery. Patients were divided into control group and aspirin group. In addition, patients in aspirin group were subdivided into nonballoon group and balloon group. Results showed that, after therapy, the increase in endometrial thickness of aspirin groups was superior to control group (P<0.05). The scores of intrauterine adhesion and menstruation were significantly improved in balloon group as compared to nonballoon group and control group, and significant differences were also observed between nonballoon group and control group (P<0.05). Of 97 patients, 44.3% became pregnant after surgery, the live birth rate was 27.8%, and the miscarriage rate was 37.2%, but there were no significant differences among three groups (P>0.05). Thus, aspirin may promote the uterine endometrial growth and repair after surgery for sIUA, and IUD in combination with intrauterine balloon may reduce the recurrence of intrauterine adhesion, but their effect on the reproductive prognosis is required to be further studied. |
| Databáze: | OpenAIRE |
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