How bioinformatics resources work with G4 RNAs
Autor: | Joanna Sarzynska, Marta Szachniuk, Joanna Miskiewicz |
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Rok vydání: | 2020 |
Předmět: |
Models
Molecular Structure analysis AcademicSubjects/SCI01060 databases Computer science Bioinformatics 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine RNA analysis Humans Computer Simulation Molecular Biology 030304 developmental biology Method Review Supplementary data quadruplexes 0303 health sciences Base Sequence RNA Computational Biology Reproducibility of Results DNA bioinformatics tools structure analysis G-Quadruplexes chemistry PQS prediction Databases Nucleic Acid 030217 neurology & neurosurgery Algorithms Information Systems |
Zdroj: | Briefings in Bioinformatics |
ISSN: | 1477-4054 |
Popis: | Quadruplexes (G4s) are of interest, which increases with the number of identified G4 structures and knowledge about their biomedical potential. These unique motifs form in many organisms, including humans, where their appearance correlates with various diseases. Scientists store and analyze quadruplexes using recently developed bioinformatic tools—many of them focused on DNA structures. With an expanding collection of G4 RNAs, we check how existing tools deal with them. We review all available bioinformatics resources dedicated to quadruplexes and examine their usefulness in G4 RNA analysis. We distinguish the following subsets of resources: databases, tools to predict putative quadruplex sequences, tools to predict secondary structure with quadruplexes and tools to analyze and visualize quadruplex structures. We share the results obtained from processing specially created RNA datasets with these tools. Contact: mszachniuk@cs.put.poznan.pl Supplementary information: Supplementary data are available at Briefings in Bioinformatics online. |
Databáze: | OpenAIRE |
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