Combined multi‐band decoupling in biomolecular NMR spectroscopy
| Autor: | Clemens Anklin, R. Andrew Byrd |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Carbon Isotopes Nitrogen Isotopes Chemistry Time-sharing Nuclear magnetic resonance spectroscopy Deuterium 010402 general chemistry Interference (wave propagation) 01 natural sciences Biochemistry Article 0104 chemical sciences 03 medical and health sciences Multi band 030104 developmental biology Data acquisition Sensitivity (control systems) Biological system Nuclear Magnetic Resonance Biomolecular Spectroscopy Decoupling (electronics) Spin-½ |
| Zdroj: | J Biomol NMR |
| ISSN: | 1573-5001 0925-2738 |
| DOI: | 10.1007/s10858-021-00360-2 |
| Popis: | Multi-resonance NMR experiments are powerful analytical and structural tools. Their conceptualization assumes that RF fields may be combined independently to manipulate spin interactions. However, practical implementation can compromise performance. One limitation is the generation of combination bands when two or more RF fields are applied simultaneously within the NMR probe. The combination bands can lead to significant interference with the detection circuitry. A facile approach to combined multi-band decoupling can resolve these problems and increase sensitivity two-fold (or more), by time sharing the application of the individual frequencies rather than time sharing decoupling and data acquisition. |
| Databáze: | OpenAIRE |
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