Do Maternal Vitamin D Levels Influence Vitamin D Levels in Preterm Neonates?
| Autor: | Malavika Panda, Alison L. Kent, Tejasvi Chaudhari, J McIntosh |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Pregnancy Neonatal intensive care unit Article Subject Obstetrics business.industry Birth weight lcsh:RJ1-570 lcsh:Pediatrics medicine.disease 03 medical and health sciences 0302 clinical medicine Parenteral nutrition 030225 pediatrics Intensive care Pediatrics Perinatology and Child Health Vitamin D and neurology medicine Gestation 030212 general & internal medicine business Prospective cohort study Research Article |
| Zdroj: | International Journal of Pediatrics International Journal of Pediatrics, Vol 2019 (2019) |
| ISSN: | 1687-9740 |
| Popis: | Objective. To determine the prevalence of Vitamin D (VitD) deficiency/insufficiency in mothers of preterm neonates less than or equal to 32 weeks of gestation and determine if the current level of VitD supplementation used for preterm neonates is appropriate.Design. Prospective study from10thMay 2015 to1stNovember 2016.Setting. Neonatal Intensive Care Unit at the Canberra Hospital.Patients. Mothers and their preterm neonates born less than or equal to 32 weeks gestation.Interventions. Maternal VitD levels were obtained within 3-4 days following delivery. Neonatal VitD levels were obtained in the first 3-4 days of life, at 3-4 weeks of age, and at 6-8 weeks of age. Demographic data and data on VitD intake from parenteral nutrition, enteral feeds, and vitamin supplementation agents were collected.Results. 70 neonates were enrolled into the study. Median gestation was 29 (27-30) weeks and median birth weight 1197 (971.2-1512.5) grams. Median maternal VitD level was 54.5 (36-70.7) nmol/L, median neonatal Vit D level at birth was 57 (42-70) nmol/L. Median Vit D level at 3 weeks and 6 weeks were 63.5 nmol/L (53-80.2) nmol/L and 103 (71.5-144) nmol/L respectively. 22/55 (40%) mothers were VitD deficient/insufficient. 25/70 (36%) neonates were VitD deficient/insufficient at birth. Of those neonates who were VitD deficient/insufficient at birth 5/25(10%) were deficient/insufficient at 6 weeks. The median intake of VitD at 6 weeks was 826.5 (577.5-939.5) IU/day.Conclusions. VitD deficiency/insufficiency in mothers of preterm neonates and in preterm neonates at birth is common. Routine screening of maternal VitD and their preterm neonates along with individualized supplementation regimens in mothers and preterm infants may optimize VitD status and reduce risk of ongoing VitD deficiency/insufficiency. |
| Databáze: | OpenAIRE |
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