Transverse aortic constriction induces gut barrier alterations, microbiota remodeling and systemic inflammation

Autor: Lorena Coretti, Mariella Cuomo, Orlando Paciello, S D'Apice, Francesca Lembo, Giuseppina Mattace Raso, Roberta Paolillo, Gina Cavaliere, Cinzia Perrino, Ilaria d'Aquino, Maria Pina Mollica, Giuseppe Giugliano, Gabriele G. Schiattarella, Giovanni Esposito, Adriano Lama, Nicola Boccella
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Lipopolysaccharide
medicine.medical_treatment
030204 cardiovascular system & hematology
Gut flora
Systemic inflammation
Mice
Feces
chemistry.chemical_compound
0302 clinical medicine
Intestinal Mucosa
Multidisciplinary
Ventricular Remodeling
biology
Pathophysiology
Cardiac hypertrophy
Cytokine
Echocardiography
Heart Function Tests
Medicine
Disease Susceptibility
medicine.symptom
Science
Article
Permeability
Proinflammatory cytokine
03 medical and health sciences
medicine
Animals
Aortic Valve Stenosis
Biomarkers
Disease Models
Disease Susceptibility
Echocardiography
Feces
Heart Failure
Inflammation
Intestinal Mucosa
Permeability
Ventricular Remodeling
Gastrointestinal Microbiome
Animals
Heart Failure
Inflammation
Pressure overload
business.industry
Aortic Valve Stenosis
biology.organism_classification
medicine.disease
Gastrointestinal Microbiome
Disease Models
Animal
stomatognathic diseases
030104 developmental biology
chemistry
Cardiovascular and Metabolic Diseases
Heart failure
Disease Models
Immunology
Dysbiosis
Metagenome
Microbiome
Metagenomics
business
Biomarkers
Zdroj: Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports
ISSN: 2045-2322
Popis: Accumulating evidence suggests that modifications of gut function and microbiota composition might play a pivotal role in the pathophysiology of several cardiovascular diseases, including heart failure (HF). In this study we systematically analysed gut microbiota composition, intestinal barrier integrity, intestinal and serum cytokines and serum endotoxin levels in C57BL/6 mice undergoing pressure overload by transverse aortic constriction (TAC) for 1 and 4 weeks. Compared to sham-operated animals, TAC induced prompt and strong weakening of intestinal barrier integrity, long-lasting decrease of colon anti-inflammatory cytokine levels, significant increases of serum levels of bacterial lipopolysaccharide and proinflammatory cytokines. TAC also exerted effects on microbiota composition, inducing significant differences in bacterial genera inside Actinobacteria, Firmicutes, Proteobacteria and TM7 phyla as shown by 16S rDNA sequencing of fecal samples from TAC or sham mice. These results suggest that gut modifications represent an important element to be considered in the development and progression of cardiac dysfunction in response to TAC and support this animal model as a valuable tool to establish the role and mechanisms of gut-heart crosstalk in HF. Evidence arising in this field might identify new treatment options targeting gut integrity and microbiota components to face adverse cardiac events.
Databáze: OpenAIRE
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