Obesity, Abdominal Obesity and Chronic Kidney Disease in Young Adults: A Nationwide Population-Based Cohort Study
| Autor: | Sang Yeob Lim, Hong Sang Choi, Soo Wan Kim, Seong Kwon Ma, Chang Seong Kim, Jin-Hyung Jung, Kyungdo Han, Tae Ryom Oh, Eun Hui Bae |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
obesity Waist 030232 urology & nephrology lcsh:Medicine Subgroup analysis body mass index Article abdominal obesity 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Internal medicine Medicine 030212 general & internal medicine Young adult Abdominal obesity business.industry lcsh:R General Medicine medicine.disease waist circumference Obesity korean diabetes mellitus medicine.symptom business Body mass index chronic kidney disease Kidney disease |
| Zdroj: | Journal of Clinical Medicine Volume 10 Issue 5 Journal of Clinical Medicine, Vol 10, Iss 1065, p 1065 (2021) |
| ISSN: | 2077-0383 |
| Popis: | Obesity has become a pandemic. It is one of the strongest risk-factors of new-onset chronic kidney disease (CKD). However, the effects of obesity and abdominal obesity on the risk of developing CKD in young adults has not been elucidated. From a nationwide health screening database, we included 3,030,884 young adults aged 20–39 years without CKD during a baseline examination in 2009–2010, who could follow up during 2013–2016. Patients were stratified into five levels based on their baseline body mass index (BMI) and six levels based on their waist circumference (WC 5-cm increments). The primary outcome was the development of CKD. During the follow up, until 2016, 5853 (0.19%) participants developed CKD. Both BMI and WC showed a U-shaped relationship with CKD risk, identifying the cut-off values as a BMI of 21 and WC of 72 cm in young adults. The obesity group (odd ratio [OR] = 1.320, 95% confidence interval [CI]: 1.247–1.397) and abdominal obesity group (male WC ≥ 90, female WC ≥ 85) (OR = 1.208, 95%CI: 1.332–1.290) showed a higher CKD risk than the non-obesity or non-abdominal obesity groups after adjusting for covariates. In the CKD risk by obesity composite, the obesity displayed by the abdominal obesity group showed the highest CKD risk (OR = 1.502, 95%CI: 1.190–1.895), especially in those under 30 years old. During subgroup analysis, the diabetes mellitus (DM) group with obesity or abdominal obesity paradoxically showed a lower CKD risk compared with the non-obesity or non-abdominal obesity group. Obesity and abdominal obesity are associated with increased risk of developing CKD in young adults but a decreased risk in young adults with diabetes. |
| Databáze: | OpenAIRE |
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