Neem Gum as a Binder in a Formulated Paracetamol Tablet with Reference to Acacia Gum BP
| Autor: | Abayomi Tolulope Ogunjimi, Gbenga Alebiowu |
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| Rok vydání: | 2014 |
| Předmět: |
Materials science
food.ingredient Chemistry Pharmaceutical Pharmaceutical Science Acacia Aquatic Science Friability Gum Arabic food Drug Discovery Ultimate tensile strength Mechanical strength Composite material Ecology Evolution Behavior and Systematics Acetaminophen Azadirachta Ecology biology Binding properties General Medicine Time ratio biology.organism_classification Gum arabic Agronomy and Crop Science Tablets Research Article |
| Zdroj: | AAPS PharmSciTech. 15:500-510 |
| ISSN: | 1530-9932 |
| DOI: | 10.1208/s12249-014-0079-x |
| Popis: | This study determined the physical, compressional, and binding properties of neem gum (NMG) obtained from the trunk of Azadirachta indica (A Juss) in a paracetamol tablet formulation in comparison with official Acacia gum BP (ACA). The physical and flow properties were evaluated using density parameters: porosity, Carr’s index, Hausner’s ratio, and flow rate. Compressional properties were analyzed using Heckel and Kawakita equations. The tensile strength, brittle fracture index, and crushing strength–friability/disintegration time ratio were used to evaluate the mechanical properties of paracetamol tablets while the drug release properties of the tablets were assessed using disintegration time and dissolution times. Tablet formulations containing NMG exhibited faster onset and higher amount of plastic deformation during compression than those containing ACA. Neem gum produced paracetamol tablets with lower mechanical strength; however, the tendency of the tablets to cap or laminate was lower when compared to those containing ACA. Inclusion of NMG improved the balance between binding and disintegration properties of paracetamol tablets produced than those containing ACA. Neem gum produced paracetamol tablets with lower disintegration and dissolution times than those containing ACA. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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