Effect of A disintegrin and metalloproteinase 10 gene silencing on the proliferation, invasion and migration of the human tongue squamous cell carcinoma cell line TCA8113
| Autor: | Yan‑Xia Bai, Xiao‑Ying Sha, Yuan Shao, Sheng‑Li Wu, Fang Quan |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Cancer Research
TCA8113 proliferation ADAM10 Cell migration Biochemistry A disintegrin and metalloproteinase 10 ADAM10 Protein Downregulation and upregulation Cell Movement Cell Line Tumor Genetics medicine Humans Gene silencing Gene Silencing Epidermal growth factor receptor RNA Small Interfering Molecular Biology Tumor Stem Cell Assay Cell Proliferation biology Cell growth Membrane Proteins Articles Cell cycle invasion Cadherins Molecular biology Tongue Neoplasms ErbB Receptors ADAM Proteins medicine.anatomical_structure Oncology Cell culture Gene Knockdown Techniques Carcinoma Squamous Cell Cancer research biology.protein Molecular Medicine RNA Interference Amyloid Precursor Protein Secretases |
| Zdroj: | Molecular Medicine Reports |
| ISSN: | 1791-3004 1791-2997 |
| DOI: | 10.3892/mmr.2014.2717 |
| Popis: | The present study aimed to investigate the effect of A disintegrin and metalloproteinase 10 (ADAM10) gene silencing on the proliferation, migration and invasion of the human tongue squamous cell carcinoma cell line TCA8113. RNA interference was used to knock down the expression of ADAM10 in the TCA8113 cell line and the proliferation, migration and invasive ability of the treated cells were observed in vitro. The expression levels of epidermal growth factor receptor (EGFR) and E-cadherin in the treated cells were determined by western blot analysis. The proliferation, migration and invasion abilities of cells in the ADAM10 siRNA-treated group were significantly lower than those in the control groups (P |
| Databáze: | OpenAIRE |
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