Urine-associated horizontal transmission of Seoul virus among rats
| Autor: | Nobuo Hashimoto, Kumiko Yoshimatsu, Ikuo Takashima, Hiroaki Kariwa, M. Fujiki, Jiro Arikawa |
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| Rok vydání: | 1998 |
| Předmět: |
Orthohantavirus
Saliva Hantavirus Infections viruses Urine Biology Virus Virology Chlorocebus aethiops Disease Transmission Infectious Animals Rats Wistar Viral shedding Respiratory Tract Infections Vero Cells Administration Intranasal Hantavirus General Medicine biology.organism_classification Animals Suckling Rats Virus Shedding Muridae Bunyaviridae Hantavirus Infection Seoul virus |
| Zdroj: | Archives of Virology. 143:15-24 |
| ISSN: | 1432-8798 0304-8608 |
| Popis: | To understand the mode of transmission of Seoul type hantavirus in Wistar rats, we examined the shedding of the virus and antibody production in infected rats. When 1-day-old rats were inoculated with KI-83-262 strain of Seoul virus, the S segment of the viral genome was detected in lungs, clots, urine, saliva, submaxillary glands, rectums, and kidneys by nested reverse transcriptase PCR. On the other hand, when 8-week-old rats were infected with the virus, viral genome was detected only in the lungs and rectum. In uninfected newborn rats intranasally administered urine from infected newborn rats, four of six rats shed the virus into their urine. In addition, three of eight rats kept in same cage with infected animals also shed the virus into urine. Moreover, the virus genome was detected in the urine of urban rats (Rattus norvegicus) in an enzootic focus. These findings suggest that the urine containing virus from infected rats is an actual source of Seoul virus infection. |
| Databáze: | OpenAIRE |
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