Activity of delta8- and delta9-tetrahydrocannabinol and related compounds in the mouse
| Autor: | JT Gidley, RI Freudenthal, Dolores R. Brine, L Testino, Monroe E. Wall, Roni Rosenfeld, HD Christensen, C Pitt, G Boegli |
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| Rok vydání: | 1971 |
| Předmět: |
Carbon Isotopes
Multidisciplinary Chromatography Gas Erythrocytes Chemistry musculoskeletal neural and ocular physiology organic chemicals Brain Pharmacology Mice nervous system Liver mental disorders Intestine Small medicine Animals Benzopyrans Chromatography Thin Layer Δ9-tetrahydrocannabinol Tetrahydrocannabinol Spleen medicine.drug Cannabis |
| Zdroj: | Science (New York, N.Y.). 172(3979) |
| ISSN: | 0036-8075 |
| Popis: | The 11-hydroxy metabolites of Delta(8).- and Delta(9)-tetrahydrocannabinol are more active than the parent compounds when administered to mice by either the intravenous or intracerebral route. Both Delta(8)- and Delta(9)-tetrahydrocannabinol are rapidly and extensively metabolized by the liver and not by the brain. The hypothesis that the 11-hydroxy metabolites may be the active form of tetrahydrocannabinol is discussed |
| Databáze: | OpenAIRE |
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