Kinetics of Postpartum Mesenteric Artery Structure and Function Relative to Pregnancy and Lactation in Mice
| Autor: | Nicole Bishop, Taylor E Dawson, Kirtika Prakash, Natalia I. Gokina, Elizabeth A. Bonney, Rebecca I Fairchild |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Vasodilator Agents Breastfeeding Maternal Biology: Original Article Vasodilation 030204 cardiovascular system & hematology Vascular structure and distensibility Constriction Mice Phenylephrine 03 medical and health sciences 0302 clinical medicine Pregnancy Postpartum Internal medicine Lactation medicine Animals Vasoconstrictor Agents 030219 obstetrics & reproductive medicine biology business.industry Postpartum Period Obstetrics and Gynecology Nitric oxide medicine.disease Acetylcholine Elastin Mesenteric Arteries medicine.anatomical_structure Endocrinology Vasoconstriction Potassium biology.protein Female Collagen medicine.symptom business Artery medicine.drug |
| Zdroj: | Reproductive Sciences |
| ISSN: | 1933-7205 1933-7191 |
| DOI: | 10.1007/s43032-020-00402-4 |
| Popis: | Epidemiological evidence suggests that normal pregnancy in women is associated with decreased cardiovascular risk in later life. Clinical studies have provided evidence that alterations in vascular function and structure are detectable long after delivery. To understand these findings, we examined mesenteric artery reactivity at both early (3 days and 2–4 weeks) and late (12 weeks) postpartum (PP) time points in relation to late pregnancy (LP) and lactation. Vessels from virgin controls, LP, PP, and nursing and non-nursing mothers were tested for responses to phenylephrine (PE), high potassium solutions (high K+), and acetylcholine (ACh). Passive arterial distensibility, vessel dimensions, and collagen and elastin content were evaluated for the studied groups. We observed that (1) there was a significant inhibition of vascular reactivity to PE in LP, 3 days and 2 weeks PP vessels that returned to pre-pregnancy levels at 4 and 12 weeks PP; (2) inhibition of NO production in PP vessels restored PE-induced constriction to pre-pregnancy levels; (3) vasodilator responses to ACh were similar at all PP periods; (4) LP and early PP was associated with a persistent increase in arterial distensibility that correlates with a PP-induced reduction in wall collagen, and regressed to pre-conception levels at 12 weeks PP; (5) vessels from non-nursing PP mice demonstrated an increased PE reactivity, diminished responses to ACh, and reduced distensibility compared to breastfeeding mice. These studies provide a timeframe for mesenteric artery adaptations that occur during pregnancy and extend to the PP period, but which may be modified by PP events. Supplementary Information The online version contains supplementary material available at 10.1007/s43032-020-00402-4. |
| Databáze: | OpenAIRE |
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