Oxidized form of 5-methylcytosine - 5-hydroxymethylcytosine: a new insight into the biological significance in the mammalian genome
| Autor: | Olga A. Efimova, Tatyana V. Kuznetzova, Anna A. Pendina, V. S. Baranov, Andrei V. Tikhonov |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
DNA Hydroxymethylation
lcsh:QH426-470 Biology Biochemistry chemistry.chemical_compound 5-carboxylcytosine environmental factors Gene expression Genetics Epigenetics 5-hydroxymethylcytosine Genetics (clinical) Ecology Evolution Behavior and Systematics Regulation of gene expression 5-Hydroxymethylcytosine Ecology active dna demethylation Human genetics 5-Methylcytosine lcsh:Genetics 5-formylcytosine chemistry epigenetic genome reprogramming in mammals gene expression Animal Science and Zoology Agronomy and Crop Science Reprogramming Cytosine DNA |
| Zdroj: | Экологическая генетика, Vol 12, Iss 1, Pp 3-13 (2014) |
| ISSN: | 2411-9202 1811-0932 |
| Popis: | The present review summarizes data on 5-hydroxymethylcytosine - a modification of cytosine with a recently discovered epigenetic effect. The biochemical mechanisms of 5-hydroxymethylcytosine formation and further modification in the mammalian genome are discussed; the role of 5-hydroxymethylcytosine in the epigenetic reprogramming during mammalian gametogenesis and early embryogenesis as well as in the regulation of gene expression is analyzed; data on the diseases and the adverse environmental factors, linked to the DNA hydroxymethyaltion disruptions is shown. |
| Databáze: | OpenAIRE |
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