Psychotic Symptoms in Alzheimer's Disease and 5-HTTLPR Polymorphism of the Serotonin Transporter Gene: Evidence for an Association
| Autor: | Camillo Marra, Carlo Masullo, Alberto Pilotto, Alessandra Bizzarro, Patrizia Mecocci, Davide Quaranta, Valeria Sebastiani, Davide Seripa, Maria Gabriella Vita |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Apolipoprotein E Psychosis medicine.medical_specialty Genotype Disease Neuropsychological Tests Logistic regression Education Apolipoproteins E Cognition Alzheimer Disease Internal medicine Activities of Daily Living medicine Humans Occupations Allele Psychiatry Alleles Serotonin transporter Aged Serotonin Plasma Membrane Transport Proteins Polymorphism Genetic Marital Status biology General Neuroscience General Medicine medicine.disease Psychiatry and Mental health Clinical Psychology Italy Psychotic Disorders 5-HTTLPR biology.protein Female Geriatrics and Gerontology Alzheimer's disease Psychology |
| Zdroj: | Journal of Alzheimer's Disease. 16:173-180 |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-2009-0950 |
| Popis: | The occurrence of psychotic symptoms is common in Alzheimer's disease (AD), configuring a possibly distinguished clinical entity defined "Psychosis in Alzheimer's Disease" (AD-P). In order to investigate demographic clinical and biological variables potentially associated to the occurrence of AD-P, 148 AD patients were selected. Mini-Mental State Examination (MMSE), Activities of Daily Living (ADL), and Instrumental Activities of Daily Living (IADL) scores, socio-economic status and 5-HTTLPR and APOE gene polymorphisms were determined for each subject. AD-P patients were significantly more frequent carriers of the long (L) allele of 5-HTTLPR. The percentage of AD-P increased with the number of copies of the L-allele: 13% among S homozygote; 36% among heterozygotes; 51% among L-homozygotes. No difference resulted between AD-P and non-psychotic AD (AD-NP) in the distribution of the epsilon4 allele of APOE. The risk of AD-P was increased in L/L homozygous (OR = 7.25, p = 0.003) and, to a lesser extent, in heterozygous (OR = 3.91; p = 0.018). Backward logistic regression analysis showed that the risk for AD-P was increased in older subjects (OR = 1.07; p = 0.018) while an increase of MMSE score was protective (OR = 0.90; p = 0.004). The occurrence of AD-P resulted significantly related to age at examination, cognitive status, and to the presence of the 5-HTTLPR L-allele. |
| Databáze: | OpenAIRE |
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