Effects of a single oral dose of gabapentin on storm phobia in dogs: A double-blind, placebo-controlled crossover trial
| Autor: | Sylvia Masson, Stephane Bleuer-Elsner, Tiphaine Medam |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Ataxia
Gabapentin Cyclohexanecarboxylic Acids 040301 veterinary sciences Analgesic Placebo 0403 veterinary science Dogs Double-Blind Method medicine Animals Amines Adverse effect Analgesics Cross-Over Studies General Veterinary business.industry 0402 animal and dairy science Storm phobia 04 agricultural and veterinary sciences General Medicine 040201 dairy & animal science Crossover study Phobic Disorders Anesthesia Anxiety medicine.symptom business medicine.drug |
| Zdroj: | The Veterinary recordREFERENCES. 189(7) |
| ISSN: | 2042-7670 |
| Popis: | Background Storm phobia in companion dogs is a common disorder that significantly impacts dogs' welfare. Gabapentin, the action of which is only partially understood, is widely used for its antiepileptic and analgesic properties. Only recently, the veterinary community began to use gabapentin to address phobia and anxiety in dogs. This study tested gabapentin to lower fear responses of dogs during a thunderstorm event. Methods Eighteen dogs suffering from storm phobia completed our double-blind, placebo-controlled crossover trial. Each dog's behaviour was evaluated twice by his owner: once under placebo, once under gabapentin. The treatment was orally administered at least 90 min before the exposure. Gabapentin was given at a dose ranging from 25 to 30 mg/kg. Results Our results indicate a significant reduction of the fear responses of dogs under gabapentin. The adverse effects were rare, and the most frequent amongst them was ataxia. Conclusion In this trial, gabapentin appears to be an efficient and safe molecule that should be considered as part of the treatment plan of storm phobia in dogs. |
| Databáze: | OpenAIRE |
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