Immunization with the transmembrane protein of a retrovirus, feline leukemia virus: Absence of antigenemia following challenge
| Autor: | Joachim Denner, Reinhard Kurth, Oswald Jarrett, Stefan Langhammer, Janine Hübner |
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| Rok vydání: | 2011 |
| Předmět: |
animal diseases
viruses Immunization Secondary Antibodies Viral Cat Diseases Feline leukemia virus Virus Retrovirus Virology Animals Viremia Neutralizing antibody Gammaretrovirus Viral Structural Proteins Pharmacology biology Leukemia Virus Feline Vaccination Viral Vaccines biology.organism_classification Antibodies Neutralizing Transmembrane protein Tumor Virus Infections Immunization Cats biology.protein Antibody Retroviridae Infections |
| Zdroj: | Antiviral Research. 89:119-123 |
| ISSN: | 0166-3542 |
| Popis: | A major challenge in the development of vaccines against retroviruses is the induction of neutralizing antibodies since they prevent infection of the cells where the virus may persist. The transmembrane envelope (TM) protein contains highly conserved domains and seems to be a suitable target. To study whether vaccinating with a TM protein of a retrovirus could protect from infection in vivo, cats were immunized with the TM protein p15E of feline leukemia virus (FeLV) and subsequently challenged. For the first time we show that immunization with a retroviral TM protein prevented antigenemia. The level of neutralizing antibodies after the boost immunization correlated with the outcome of FeLV infection. |
| Databáze: | OpenAIRE |
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