Angiotensin II can induce and potentiate shape change in human platelets: effect of losartan
| Autor: | Dimitri P. Mikhailidis, IA Jagroop |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Blood Platelets Male medicine.medical_specialty Serotonin Antagonists & inhibitors Indomethacin Pharmacology Losartan Thromboxane A2 chemistry.chemical_compound Internal medicine Internal Medicine Medicine Humans Platelet Platelet activation Mean platelet volume Cell Size business.industry Angiotensin II Drug Synergism Middle Aged Adenosine Diphosphate Endocrinology chemistry Platelet-rich plasma Female business medicine.drug |
| Zdroj: | Journal of human hypertension. 14(9) |
| ISSN: | 0950-9240 |
| Popis: | Platelet shape change (PSC) is an early phase of platelet activation that precedes platelet aggregation. This phase of platelet activation is essentially aspirin resistant. PSC was monitored, by measuring the median platelet volume (MPV) using a high resolution channelyser. Angiotensin (Ang) II, added in vitro, caused a significant (P = 0.004) increase in MPV in platelet rich plasma prepared from healthy subjects (n = 14). This increase in MPV was marked (>0.40 fl) in 57% (n = 8) of these subjects and was significantly inhibited (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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