In vitro susceptibility of thirtyBorrelia strains from various sources against eight antimicrobial chemotherapeutics
| Autor: | Gerold Stanek, R Baradaran-Dilmaghani |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Microbiology (medical)
Time Factors Cefotaxime medicine.drug_class Antibiotics Microbial Sensitivity Tests Azithromycin Biology medicine.disease_cause Microbiology Ticks Borrelia burgdorferi Group Trimethoprim Sulfamethoxazole Drug Combination polycyclic compounds medicine Animals Humans Borrelia burgdorferi Lyme Disease Roxithromycin Borrelia Ceftriaxone Amoxicillin Penicillin G General Medicine bacterial infections and mycoses biology.organism_classification Antimicrobial Virology Anti-Bacterial Agents Infectious Diseases Doxycycline Lyme disease microbiology Borrelia garinii medicine.drug |
| Zdroj: | Infection. 24:60-63 |
| ISSN: | 1439-0973 0300-8126 |
| DOI: | 10.1007/bf01780660 |
| Popis: | Minimal inhibitory concentrations (MIC) and minimal bactericidal concentrations (MBC) were evaluated of the antimicrobial chemotherapeutics amoxicillin, azithromycin, cefotaxime, ceftriaxone, doxycycline, penicillin G sodium, roxithromycin, and trimethoprim-sulfamethoxazole for 30 Borrelia strains from various sources (skin, cerebrospinal fluid, ticks). Of these strains 29 were Lyme disease agents of the species Borrelia afzelii (n = 12), Borrelia burgdorferi sensu stricto (n = 4), Borrelia garinii (n = 13), and one was the relapsing fever strain Borrelia turicatae (n = 1). Tests were performed in microtiter plates by broth dilution. MIC was determined after 72 hours of incubation by comparing growth control with the antibiotic dilutions by means of dark field microscopy. Strains tested were susceptible against amoxicillin, azithromycin, cefotaxime, ceftriaxone, doxycycline, and penicillin G sodium, partly susceptible to roxithromycin, and resistant to trimethoprim-sulfamethoxazole. No statistically significant differences in MIC and MBC were seen among the different antibiotics with the various Borrelia species. |
| Databáze: | OpenAIRE |
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