FORMULATION AND DETAILED CHARACTERIZATION OF VORICONAZOLE LOADED IN SITU GELS FOR OCULAR APPLICATION
| Autor: | Vildan Yozgatli, Zeynep Şenyiğit, Neslihan Üstündağ Okur |
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| Přispěvatelé: | Ege Üniversitesi |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Ankara Universitesi Eczacilik Fakultesi Dergisi. :33-49 |
| ISSN: | 1015-3918 |
| DOI: | 10.33483/jfpau.586590 |
| Popis: | Objective: This study was aimed to prepare, characterize and evaluate in situ gel formulation for a sustained ocular delivery of voriconazole. Material and Method: In situ gels were prepared with three different hydrophilic co-polymers: Poloxamer 188, 407 and 388. The formulations were characterized in terms of their clarity, pH, viscosity drug content uniformity and mechanical/rheological properties. Moreover, in vitro drug release and stabilitystudies were performed. Result and Discussion: The results showed that the optimized in situ gel formulation had desired in vitro properties and a good stability over the period of 3 months. Texture profile analysis presented that formulations offered suitable adhesive and mechanical properties. P2-V formulation exhibited pseudo-plastic flow and typical gel-type mechanical spectra (G? > G?) at different frequecy values and at different temperatures. Moreover, all formulations showed a sustained drug release for 24 hours. In conclusion, voriconazole loaded in situ gel could be offered as an encouraging strategy as ocular systems for ocular infections treatment. © 2020 University of Ankara. All rights reserved. BASF The authors would like to thank to the BASF for providing the poloxamers. |
| Databáze: | OpenAIRE |
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