Genetic analysis of type O viruses responsible for epidemics of foot-and-mouth disease in North Africa
| Autor: | Nick J. Knowles, A. R. Samuel, D. K. J. Mackay |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Serotype
Buffaloes Epidemiology Type (model theory) Disease cluster Virus Disease Outbreaks Aphthovirus Africa Northern medicine Animals Cluster Analysis Longitudinal Studies Phylogeny Sheep Molecular epidemiology Foot-and-mouth disease Goats Outbreak medicine.disease Virology Infectious Diseases Geography Foot-and-Mouth Disease RNA Viral Cattle Viral disease Research Article |
| Zdroj: | Epidemiology and Infection. 122:529-538 |
| ISSN: | 1469-4409 0950-2688 |
| DOI: | 10.1017/s0950268899002265 |
| Popis: | The nucleotide sequences of the 3′ end of the capsid-coding region were determined for 30 serotype O foot-and-mouth disease (FMD) viruses isolated between 1987 and 1994 from outbreaks in North Africa and the Middle East. These sequences were compared with the previously published sequences of 9 field virus isolates from the Middle East and 5 vaccine virus strains, 3 of which originated from the Middle East (O1/Turkey/Manisa/69, O1/Sharquia/Egypt/72 and O1/Israel/2/85) and 2 from Europe (O1/Lausanne/Switzerland/65 and O2/Brescia/Italy/47). Cluster analysis of these sequences using the unweighted pair group mean average (UPGMA) method showed: (i) that the FMD viruses isolated from North Africa and the Middle East were very different from the classical European vaccine strains; (ii) that all the viruses isolated during the 1989–92 North African epidemic formed a cluster differing by no more than 6% from each other; (iii) a virus isolated in Libya in 1988 was unrelated to the aforementioned epidemic; and (iv) viruses from a second, less extensive epidemic, occurring in 1994, fell into yet another cluster. |
| Databáze: | OpenAIRE |
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