Maintenance of Potassium Balance during Diuretic Therapy
| Autor: | Antti Kohvakka, Antti Eisalo, Vesa Manninen |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Dose medicine.medical_treatment Potassium chemistry.chemical_element Hypokalemia Spironolactone 030204 cardiovascular system & hematology Pharmacology Essential hypertension Potassium Chloride Amiloride Placebos 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Hydrochlorothiazide Internal medicine Internal Medicine medicine Humans 030212 general & internal medicine Aged Triamterene Clinical Trials as Topic business.industry Middle Aged medicine.disease 3. Good health Drug Combinations Endocrinology chemistry Pyrazines Hypertension Drug Evaluation Drug Therapy Combination Female Diuretic business medicine.drug |
| Zdroj: | Acta Medica Scandinavica. 205:319-324 |
| ISSN: | 0001-6101 |
| DOI: | 10.1111/j.0954-6820.1979.tb06056.x |
| Popis: | The relative efficacies of potassium chloride, amiloride, triamterene and spironolactone in maintaining potassium balance were studied in 40 patients with essential hypertension receiving diuretic therapy. The preparations were administered in random order in a cross-over manner. In 31 patients treated with 50 mg hydrochlorothiazide daily, addition of 1500 mg potassium chloride daily was the weakest and 50 mg spironolactone daily the most effective agent for maintaining serum potassium. Amiloride (5 mg daily) and triamterene (75 mg daily) were less effective and equally so. Similar results were obtained with 9 patients treated with double dosages of the diuretic and supplements. Despite changes in serum potassium, total body potassium remained constant throughout the trial. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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