Assessing the dynamic changes in vitiligo : reliability and validity of the Vitiligo Disease Activity Score (VDAS) and Vitiligo Disease Improvement Score (VDIS)

Autor: N. van Geel, L. Depaepe, V. Vandaele, L. Mertens, J. Van Causenbroeck, S. De Schepper, L. Van Coile, A. Van Reempts, A.‐S. De Vos, J. Papeleu, I. Hoorens, D. Mertens, A. Wolkerstorfer, J.E. Lommerts, R. Speeckaert
Přispěvatelé: Dermatology, AII - Inflammatory diseases
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
Journal of the European Academy of Dermatology and Venereology, 36(8), 1334-1341. Wiley-Blackwell
van Geel, N, Depaepe, L, Vandaele, V, Mertens, L, van Causenbroeck, J, de Schepper, S, van Coile, L, van Reempts, A, de Vos, A S, Papeleu, J, Hoorens, I, Mertens, D, Wolkerstorfer, A, Lommerts, J E & Speeckaert, R 2022, ' Assessing the dynamic changes in vitiligo : reliability and validity of the Vitiligo Disease Activity Score (VDAS) and Vitiligo Disease Improvement Score (VDIS) ', Journal of the European Academy of Dermatology and Venereology, vol. 36, no. 8, pp. 1334-1341 . https://doi.org/10.1111/jdv.18134
ISSN: 0926-9959
1468-3083
DOI: 10.1111/jdv.18134
Popis: Background: The assessment of the individual evolution of vitiligo is important for therapeutic decision making in daily practice. A fast, simple and validated physician-reported score to assess clinical changes in depigmentation over time in separate parts (activity and improvement) is currently missing. Objective: The main objective of the study was to develop and validate the Vitiligo Disease Activity Score (VDAS) and Vitiligo Disease Improvement Score (VDIS). Methods: The Vitiligo Disease Activity Score (VDAS) and Vitiligo Disease Improvement Score (VDIS) were evaluated based on a photo set of 66 patients with two different time points. In the first (short) version, only the number of changing body regions was counted based on 15 predefined areas (VDAS₁₅ and VDIS₁₅), while in the second (extensive) version the degree of worsening or improvement from +4 to −4 for each body area was added for a more detailed assessment (VDAS₆₀ and VDIS₆₀). Content and construct validity were tested. In addition inter-, intrarater reliability and feasibility were evaluated by 7 (test) and 5 (retest) physicians. Results: Evidence for content and construct validity was provided. Overall, VDAS₁₅, VDIS₁₅, VDAS₆₀ and VDIS₆₀ demonstrated good to excellent inter-rater reliability [intraclass correlation (ICC): VDAS: range = 0.797–0.900; VDIS: range = 0.726–0.798]. The intrarater reliability ICCs were 0.865 and 0.781 for the VDAS₁₅ and VDIS₁₅, respectively. Similar results were obtained for the VDAS₆₀ and VDIS₆₀ (ICC = 0.913 and 0.800, respectively). Completion time was short (median: 122 s/patient (first round); 95 s/patient (second round)]. Limitations: Single tertiary centre mainly of skin phototype 2 to 3. Conclusion: The VDAS and VDIS appear to be valid, reliable and feasible instruments to score the evolution of vitiligo lesions. This accommodates the current urgent need for a simple, standardized and practical assessment of vitiligo activity and improvement over time. in press
Databáze: OpenAIRE
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