Strain estimation in phase-sensitive optical coherence elastography
| Autor: | Sze Howe Koh, Robert A. McLaughlin, Kelsey M. Kennedy, Brendan F. Kennedy, David D. Sampson, Peter R. T. Munro |
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| Rok vydání: | 2012 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.diagnostic_test Dynamic range Image quality Mathematical analysis ocis:(170.6935) Tissue characterization Finite difference ocis:(110.4500) Optical coherence tomography Atomic and Molecular Physics and Optics ocis:(290.5820) Scattering measurements Optical coherence tomography Phase noise Ordinary least squares medicine Optical Coherence Tomography Elasticity (economics) Refractive index Biotechnology Mathematics |
| Zdroj: | Biomedical Optics Express |
| ISSN: | 2156-7085 |
| DOI: | 10.1364/boe.3.001865 |
| Popis: | We present a theoretical framework for strain estimation in optical coherence elastography (OCE), based on a statistical analysis of displacement measurements obtained from a mechanically loaded sample. We define strain sensitivity, signal-to-noise ratio and dynamic range, and derive estimates of strain using three methods: finite difference, ordinary least squares and weighted least squares, the latter implemented for the first time in OCE. We compare theoretical predictions with experimental results and demonstrate a ~12 dB improvement in strain sensitivity using weighted least squares compared to finite difference strain estimation and a ~4 dB improvement over ordinary least squares strain estimation. We present strain images (i.e., elastograms) of tissue-mimicking phantoms and excised porcine airway, demonstrating in each case clear contrast based on the sample's elasticity. |
| Databáze: | OpenAIRE |
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