Ethological analysis of scopolamine treatment or pretreatment in morphine dependent rats
| Autor: | Wei-Ran Wu, Hui-Ling Wang, Yan Zhao, Xiao-Hui Xiang, Hui-Sheng Wang, Dong-Yuan Cao, Yuan Guo |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Narcotics Narcotic Antagonists media_common.quotation_subject Scopolamine Drinking Experimental and Cognitive Psychology Behavioral Symptoms Muscarinic Antagonists (+)-Naloxone Pharmacology Irritability Parasympatholytic Rats Sprague-Dawley Excretion Behavioral Neuroscience medicine Animals Drug Interactions media_common Analysis of Variance Behavior Animal Morphine Naloxone Addiction Alkaloid Ethology Rats Disease Models Animal medicine.symptom Psychology Morphine Dependence Scopolamine Hydrobromide medicine.drug |
| Zdroj: | Physiology & Behavior. 88:183-190 |
| ISSN: | 0031-9384 |
| DOI: | 10.1016/j.physbeh.2006.03.029 |
| Popis: | Although scopolamine is currently used to treat morphine addiction in humans, its extensive actions on behaviors have not been systematically analyzed yet, and the underlying mechanisms of its effects still remain ambiguous. The present study was carried out to clarify the possible mechanisms by evaluating the effects of scopolamine pretreatment and treatment on naloxone-precipitated withdrawal signs and some of other general behaviors in morphine dependent rats. Our results showed that scopolamine pretreatment and treatment attenuated naloxone-precipitated withdrawal signs including jumping, writhing posture, weight loss, genital grooming, teeth-chattering, ptosis, diarrhea and irritability, except for wet dog shakes, while general behaviors such as water intake, urine volume and morphine excretion in urine were increased. Our findings suggest that scopolamine has significant actions in the treatment of opiate addiction, which might result from increasing morphine excretion from urine. |
| Databáze: | OpenAIRE |
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