Assessment of Chimpanzee Adenovirus Serotype 63 Neutralizing Antibodies Prior to Evaluation of a Candidate Malaria Vaccine Regimen Based on Viral Vectors

Autor:	Alfred B. Tiono, Adrian V. S. Hill, Katie J. Ewer, Guillaume S. Sanou, Souleymane Sanon, Sodiomon B. Sirima, Nick J. Edwards, Egeruan B. Imoukhuede, Jean Baptiste Yaro, David T. Kangoye, Issa Nebie, Issiaka Soulama, Amidou Diarra
Rok vydání:	2014
Předmět:	Adult Microbiology (medical) Serotype Adolescent Pan troglodytes Clinical Biochemistry Immunology Antibodies Viral Viral vector Cohort Studies Young Adult Burkina Faso Malaria Vaccines parasitic diseases Animals Humans Immunology and Allergy Medicine Vector (molecular biology) Malaria Falciparum Child Neutralizing antibody Vaccines biology Malaria vaccine business.industry Vaccine trial Infant Middle Aged Antibodies Neutralizing Virology Titer Child Preschool biology.protein Adenoviruses Simian population characteristics Antibody business
Zdroj:	Clinical and Vaccine Immunology. 21:901-903
ISSN:	1556-679X 1556-6811
DOI:	10.1128/cvi.00723-13
Popis:	Prior to a chimpanzee adenovirus-based (ChAd63) malarial vaccine trial, sera were collected to assess ChAd63-specific neutralizing antibody titers in Banfora (Burkina Faso). The low neutralizing antibody titers reported in both adults and children (median titers, 139.1 and 35.0, respectively) are encouraging for the potential use of ChAd63 as a malarial vaccine vector.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::360492685eafbf989193b65884259b57 https://doi.org/10.1128/cvi.00723-13 Zobrazit plný text záznamu