Central administration of ibuprofen failed to block the anorexia induced by interleukin-1
| Autor: | Shimomura Yohnosuke, Kobayashi Isao, Shimizu Hiroyuki, Uehara Yutaka |
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| Rok vydání: | 1991 |
| Předmět: |
Male
Food intake medicine.medical_specialty Prostaglandin Ibuprofen Anorexia law.invention chemistry.chemical_compound Eating law Internal medicine medicine Animals Cyclooxygenase Inhibitors Injections Intraventricular Pharmacology biology business.industry Body Weight Interleukin Rats Inbred Strains Recombinant Proteins Peripheral Rats Endocrinology chemistry biology.protein Recombinant DNA Prostaglandins Cyclooxygenase medicine.symptom business Injections Intraperitoneal medicine.drug Interleukin-1 |
| Zdroj: | European journal of pharmacology. 195(2) |
| ISSN: | 0014-2999 |
| Popis: | Interleukins are synthesized by inflammatory cells and are thought to be involved in the anorexia associated with severe infection. In the present study, the possible involvement of prostaglandins in the anorexia caused by interleukin-1 was investigated. Recombinant human interleukin-1β (IL-1β), 17 ng/rat, injected into the third cerebroventricles significantly suppressed food intake and reduced the body weight gain in rats deprived of food for 18 h. Central administration of ibuprofen (IBP, 5–500 μg/rat), a selective cyclooxygenase blocker, failed to attenuate the feeding suppression and body weight loss induced by IL-1β injection, although central administration of 50 μg IBP blocked the increase of body temperature caused by central IL-1β. In contrast, i.p. injection of IBP (10 mg/kg) partially blocked the anorexia and body weight loss caused by IL-1β. The data obtained suggest that a peripheral prostaglandin synthesizing system may play an important role in the anorexia caused by IL-1β. |
| Databáze: | OpenAIRE |
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