1H, 13C, and 15N Backbone assignments of the human brain and acute leukemia cytoplasmic (BAALC) protein
| Autor: | Jan Jirschitzka, Andras Lang, Christoph Wiedemann, Frank Bordusa, Oliver Ohlenschläger, Amit Kumar |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Gene isoform
0303 health sciences Acute leukemia Myeloid Chemistry Resonance assignments Neuroectodermal and hematopoietic cell function Biochemistry Article Heteronuclear NMR Cell biology 03 medical and health sciences Haematopoiesis 0302 clinical medicine medicine.anatomical_structure Structural Biology Cytoplasm 030220 oncology & carcinogenesis Intrinsically disordered protein (IDP) medicine Lymphoid Progenitor Cells Function (biology) BAALC Brain and acute leukemia cytoplasmic protein (BAALC) 030304 developmental biology |
| Zdroj: | Biomolecular Nmr Assignments |
| ISSN: | 1874-270X 1874-2718 |
| Popis: | The brain and acute leukemia cytoplasmic (BAALC; UniProt entry Q8WXS3) is a 180-residue-long human protein having six known isoforms. BAALC is expressed in either hematopoietic or neuroectodermal cells and its specific function is still to be revealed. However, as a presumably membrane-anchored protein at the cytoplasmic side it is speculated that BAALC exerts its function at the postsynaptic densities of certain neurons and might play a role in developing cytogenetically normal acute myeloid leukemia (CN-AML) when it is highly overexpressed by myeloid or lymphoid progenitor cells. In order to better understand the physiological role of BAALC and to provide the basis for a further molecular characterization of BAALC, we report here the 1H, 13C, and 15N resonance assignments for the backbone nuclei of its longest hematopoietic isoform (isoform 1). In addition, we present a 1HN and 15NH chemical shift comparison of BAALC with its shortest, neuroectodermal isoform (isoform 6) which shows only minor changes in the 1H and 15N chemical shifts. |
| Databáze: | OpenAIRE |
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