Natriuretic peptide and adrenomedullin levels in chronic renal failure and effects of peritoneal dialysis
| Autor: | Timothy C. R. Prickett, Timothy G. Yandle, Steve Fisher, Chris Frampton, Vicky A. Cameron, Javed Y. Pathan, M G Nicholls, Enyioma N. Obineche |
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| Rok vydání: | 2006 |
| Předmět: |
Nephrology
Adult Male medicine.medical_specialty medicine.drug_class medicine.medical_treatment N-terminal CNP Urology N-terminal BNP Peritoneal dialysis chemistry.chemical_compound Adrenomedullin Atrial natriuretic peptide Internal medicine Natriuretic Peptide Brain medicine Natriuretic peptide Humans Aged Creatinine business.industry Natriuretic Peptide C-Type Middle Aged Brain natriuretic peptide medicine.disease Peptide Fragments Endocrinology chemistry CNP Kidney Failure Chronic Female business Peptides Peritoneal Dialysis hormones hormone substitutes and hormone antagonists Kidney disease BNP |
| Zdroj: | Kidney International. 69(1):152-156 |
| ISSN: | 0085-2538 |
| DOI: | 10.1038/sj.ki.5000009 |
| Popis: | Plasma levels of B-type natriuretic peptide (BNP) and its N-terminal propeptide (NT-BNP) are elevated in renal impairment and provide a robust prognostic index. The effect of peritoneal dialysis on plasma NT-BNP, however, is unknown. Furthermore, no information exists regarding levels of the N-terminal propeptide for C-type natriuretic peptide (NT-CNP) in renal failure and the effects of peritoneal dialysis. Accordingly, we documented venous levels of these peptides, and adrenomedullin, across peritoneal dialysis. We measured venous BNP, NT-BNP, NT-CNP, adrenomedullin, blood urea nitrogen (BUN) and creatinine before, during and after completion of overnight peritoneal dialysis in 11 patients, and identical sampling was carried out in eight patients (controls) but between peritoneal dialysis treatments. Peptide levels were measured using well-validated, published methods. Baseline levels of NT-CNP (212, 150–303 pmol/l, median and 25th and 75th percentiles) were much higher than recorded previously in healthy volunteers or in heart failure, and correlated with plasma creatinine (rs=0.53, P |
| Databáze: | OpenAIRE |
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