Microsatellite Instability Status in Gastric Cancer: A Reappraisal of Its Clinical Significance and Relationship with Mucin Phenotypes
| Autor: | Won-Young Park, Jee-Yeon Kim, Ahrong Kim, Joo-Yeun Kim, Chang Hun Lee, Nari Shin, Hyun-Jeong Lee, Gi-Young Huh, Do Youn Park |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities Pathology medicine.medical_specialty Survival Adenocarcinoma Pathology and Forensic Medicine medicine Clinical significance neoplasms business.industry Stomach Mucin nutritional and metabolic diseases Cancer Microsatellite instability medicine.disease Phenotype digestive system diseases medicine.anatomical_structure Microsatellite Original Article business |
| Zdroj: | Korean Journal of Pathology |
| ISSN: | 2092-8920 1738-1843 |
| Popis: | Background Gastric cancers with microsatellite instabilities (MSI) have been reported to be associated with favorable prognosis. However, the significance of the effect of MSI on the clinicopathological features, as well as its association with mucin phenotype, remains unclear. Methods MSI status was assessed in 414 cases of gastric cancer using polymerase chain reaction analysis of five microsatellite loci, as recommended by National Cancer Institution criteria. The expression of mucins (MUC5AC, MUC6, MUC2, and CD10) was assessed. Results Out of 414 total cases of gastric cancer, 380 (91.7%), 11 (2.7%), and 23 (5.6%) were microsatellite stable (MSS), low-level MSI (MSI-L), and high-level MSI (MSI-H), respectively. Compared to MSS/MSI-L, MSI-H gastric cancers were associated with older age (p=0.010), tumor size (p=0.014), excavated gross (p=0.042), intestinal type (p=0.028), aggressive behaviors (increase of T stage [p=0.009]), perineural invasion [p=0.022], and lymphovascular emboli [p=0.027]). MSI-H gastric cancers were associated with tumor necrosis (p=0.041), tumor-infiltrating lymphocytes (≥2/high power field, p |
| Databáze: | OpenAIRE |
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