Comparison of Clinical, Histopathological, and Genomic Features Between Malignant Peripheral Nerve Sheath Tumors and Cellular Schwannomas of the Eighth Cranial Nerve: A Case Series
| Autor: | Yang Chen, Pinan Liu, Luo Lin, Qiyang He, Li Zhang, Bo Wang, Shun Zhang, Yanbing Yu, fu zhao, Jing Zhang, Jiang Du |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology H&E stain Malignant peripheral nerve sheath tumor Nerve Sheath Neoplasms Loss of heterozygosity 03 medical and health sciences 0302 clinical medicine Peripheral Nervous System Neoplasms otorhinolaryngologic diseases medicine Peripheral Nerve Sheath Tumors Humans Eighth cranial nerve business.industry Genomics Middle Aged Vestibulocochlear Nerve medicine.disease 030220 oncology & carcinogenesis Immunohistochemistry Female Surgery Histopathology Neurology (clinical) business Neurilemmoma 030217 neurology & neurosurgery Follow-Up Studies Comparative genomic hybridization |
| Zdroj: | World Neurosurgery. 122:e487-e497 |
| ISSN: | 1878-8750 |
| DOI: | 10.1016/j.wneu.2018.10.087 |
| Popis: | Background Malignant peripheral nerve sheath tumors (MPNSTs) and cellular schwannomas (CSs) of the eighth cranial nerve are exceedingly rare. The purpose of the present study was to evaluate clinical and genetic characterization of these rare tumors. Methods The clinical and radiological features were analyzed retrospectively. The histopathological characteristics were assessed by hematoxylin and eosin staining and immunohistochemistry. Genomic abnormalities were evaluated using array comparative genomic hybridization. Results Of the 1287 surgeries for vestibular schwannomas from 2014 to 2017, 2 were for MPNSTs and 5 were for CSs. The mean age at diagnosis was older for patients with MPNSTs (57.0 ± 4.2 years) than that of patients with CS (35.8 ± 9.4 years; P = 0.03). Two patients with MPNST died of tumor recurrence. None of the patients with CS died. The 2-year overall and progression-free survival of patients with MPNSTs were worse than those for patients with CSs (overall survival, 50.0% ± 35.4% vs. 100%, P = 0.027; progression-free survival, 0% vs. 100%; P = 0.012). The Ki-67 index for the MPNSTs (29.0% ± 3.5%) was greater than that for the CSs (10.3% ± 3.1%; P = 0.001). The common alterations in MPNSTs mainly included gains of chromosomes 7p, 8p, 9q, 12, and 17 and loss of heterozygosity of 1p, 6 and 9p. The common alterations in CSs included gain of 4p16.3, loss of heterozygosity of 2p15-14, and 22q11.1-13.3. Conclusions To the best of our knowledge, the present study is the first high-resolution genomic analysis of MPNSTs and CSs of the eighth cranial nerve and has shown a significant difference that might be more accurate to distinguish between these 2 types of rare tumors. |
| Databáze: | OpenAIRE |
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