Cardiac Functions Assessment in Children with Celiac Disease and its Correlation with the Degree of Mucosal Injury: Doppler Tissue Imaging Study
| Autor: | Hany M. Abo-Haded, Abeer Fathy, Marwa M. El-Sonbaty, Najat Al-Ahmadi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Pathology Heart Ventricles Saudi Arabia Disease 030204 cardiovascular system & hematology Both ventricles Correlation 03 medical and health sciences 0302 clinical medicine Doppler tissue imaging Statistical significance Internal medicine Medicine Humans Prospective Studies lcsh:RC799-869 Child Subclinical infection business.industry Gastroenterology Fractional shortening Echocardiography Doppler Celiac Disease Case-Control Studies Cardiology 030211 gastroenterology & hepatology Tei index lcsh:Diseases of the digestive system. Gastroenterology Original Article Female business Cardiomyopathies subclinical cardiac affection |
| Zdroj: | Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association The Saudi Journal of Gastroenterology, Vol 22, Iss 6, Pp 441-447 (2016) |
| ISSN: | 1998-4049 1319-3767 |
| Popis: | Background/Aims: Celiac disease (CD)-associated cardiologic disorders is a growing concern. However, data regarding cardiac affection in children with CD are few. This study aimed at assessing the subclinical impact of CD on the global myocardial performance in Saudi children with CD using Doppler tissue imaging (DTI). Patients and Methods: Conventional two-dimensional echocardiography was performed among 20 Saudi children with CDas well as 20 age and sex-matched healthy controls. DTI were used to determine right ventricular (RV) and left ventricular (LV) Tei indexes. These findings were correlated with the Modified Marsh Classification of the histologic findings in CD. Results: LV and RV Tei indexes were significantly higher in children with CD than the control group (mean ± standard deviation: 0.47 ± 0.05 vs. 0.31 ± 0.18; P < 0.0005 and 0.51 ± 0.04 vs. 0.32 ± 0.05; P < 0.0001, respectively). RV Tei index was found to be positively correlated with the Modified Marsh Classification of CD (r = 0.7753, P < 0.0001). LV Tei index tended to be more affected in patients with more severe histologic findings, however, such relation did not reach statistical significance (r = 0.2479, P = 0.292). Fractional shortening did not correlate with the Modified Marsh Classification of histologic findings in CD patients (r= −0.11, P = 0.641). Conclusions: Subclinical myocardial dysfunction of both ventricles occurs in children with CD. The DTI method appears to be more sensitive than conventional two-dimensional echocardiography in the early detection of myocardial dysfunction in children with CD. |
| Databáze: | OpenAIRE |
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