Diverse relationships between metal ions and the ribosome
| Autor: | Genki Akanuma |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
inorganic chemicals
0301 basic medicine Metal ions in aqueous solution Cellular homeostasis Applied Microbiology and Biotechnology Biochemistry Ribosome Analytical Chemistry 03 medical and health sciences Ribosomal protein Gene expression Homeostasis Magnesium Molecular Biology Protein secondary structure 030102 biochemistry & molecular biology Chemistry Organic Chemistry Translation (biology) General Medicine Ribosomal RNA Zinc 030104 developmental biology Biophysics Ribosomes Biotechnology |
| Zdroj: | Bioscience, Biotechnology, and Biochemistry. 85:1582-1593 |
| ISSN: | 1347-6947 |
| Popis: | The ribosome requires metal ions for structural stability and translational activity. These metal ions are important for stabilizing the secondary structure of ribosomal RNA, binding of ribosomal proteins to the ribosome, and for interaction of ribosomal subunits. In this review, various relationships between ribosomes and metal ions, especially Mg2+ and Zn2+, are presented. Mg2+ regulates gene expression by modulating the translational stability and synthesis of ribosomes, which in turn contribute to the cellular homeostasis of Mg2+. In addition, Mg2+ can partly complement the function of ribosomal proteins. Conversely, a reduction in the cellular concentration of Zn2+ induces replacement of ribosomal proteins, which mobilizes free-Zn2+ in the cell and represses translation activity. Evolutional relationships between these metal ions and the ribosome are also discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|