Iron-catalyzed synthesis of oxindoles: application to the preparation of pyrroloindolines

Autor:	Caio A. E Barata, Leandro H. Andrade, Juliana C. Abreu, Valquírio G. Correia
Rok vydání:	2017
Předmět:	Tandem 010405 organic chemistry Chemistry Iron catalyzed Radical Organic Chemistry Ether 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences chemistry.chemical_compound Organic chemistry Physical and Theoretical Chemistry ALCALOIDES DE PIRROLIZIDINA Iron catalyst
Zdroj:	Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP
Popis:	A novel and highly efficient synthetic approach to pyrroloindolines has been developed. The process is based on tandem radical addition/cyclization with inexpensive iron catalyst. This method tolerates a wide range of N-methyl-N-arylacrylamides as well carbamoyl radicals, providing access to a variety of functionalized 3,3-disubstituted oxindoles, key intermediates for many bioactive pyrroloindolines such as (±)-esermethole, (±)-deoxyeseroline, and (±)-physovenol methyl ether.
Databáze:	OpenAIRE
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