Epidermal Growth Factor and Erythropoietin Infusion Accelerate Functional Recovery in Combination With Rehabilitation
| Autor: | Cindi M. Morshead, Amy Hoyles, Matthew S. Jeffers, Dale Corbett |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Ischemia Motor Activity Rats Sprague-Dawley Epidermal growth factor medicine Animals Erythropoietin Stroke Advanced and Specialized Nursing Rehabilitation Endothelin-1 Epidermal Growth Factor business.industry Growth factor Stroke Rehabilitation medicine.disease Rats Surgery Disease Models Animal medicine.anatomical_structure Ventricle Anesthesia Chronic Disease Neurology (clinical) Forelimb Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Stroke. 45:1856-1858 |
| ISSN: | 1524-4628 0039-2499 |
| DOI: | 10.1161/strokeaha.114.005464 |
| Popis: | Background and Purpose— Rehabilitation is the only treatment option for chronic stroke deficits, but unfortunately, it often provides incomplete recovery. In this study, a novel combination of growth factor administration and rehabilitation therapy was used to facilitate functional recovery in a rat model of cortical stroke. Methods— Ischemia was induced via injection of endothelin-1 into the sensorimotor cortex. This was followed by either a 2-week infusion of epidermal growth factor and erythropoietin or artificial cerebrospinal fluid into the ipsilateral lateral ventricle. Two weeks after ischemia, animals began an 8-week enriched rehabilitation program. Functional recovery was assessed after ischemia using the Montoya staircase-reaching task, beam-traversing, and cylinder test of forelimb asymmetry. Results— The combination of growth factor infusion and rehabilitation led to a significant acceleration in recovery in the staircase task. When compared with controls, animals receiving the combination treatment attained significant recovery of function at 4 weeks after stroke, whereas those receiving rehabilitation alone did not recover until 10 weeks. Significant recovery was also observed on the beam-traversing and cylinder tasks. Conclusions— Combining behavioral rehabilitation with growth factor infusion accelerates motor recovery. These data suggest a promising new avenue of combination therapies that may have the potential to reduce the rehabilitation time necessary to recover from sensorimotor deficits arising from stroke. |
| Databáze: | OpenAIRE |
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