Protective effects of astaxanthin on skin deterioration
| Autor: | Yuki Adachi, Kumi Tominaga, Nobuko Hongo, Yu Takahashi, Mayuko Fujishita |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Antioxidant inflammatory cytokines interleukin-1α medicine.medical_treatment Clinical Biochemistry Medicine (miscellaneous) Pharmacology Placebo skin elasticity 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Astaxanthin Stratum corneum medicine Carotenoid Wrinkle chemistry.chemical_classification Nutrition and Dietetics integumentary system business.industry astaxanthin wrinkle formation 030104 developmental biology medicine.anatomical_structure chemistry Biochemistry Original Article Cytokine secretion medicine.symptom business Keratinocyte |
| Zdroj: | Journal of Clinical Biochemistry and Nutrition |
| ISSN: | 1880-5086 0912-0009 |
| Popis: | Astaxanthin is a carotenoid with potent antioxidant and anti-inflammatory activity. To evaluate the anti-inflammatory effect of astaxanthin on skin deterioration, we confirmed its role in epidermal-dermal interactions in vitro. Astaxanthin treatment suppressed ultraviolet B (UVB)-induced inflammatory cytokine secretion in keratinocytes, and matrix metalloproteinase-1 secretion by fibroblasts cultured in UVB-irradiated keratinocyte medium. To verify these findings, we conducted a 16-week clinical study with 65 healthy female participants. Participants were orally administered either a 6 mg or 12 mg dose of astaxanthin or a placebo. Wrinkle parameters and skin moisture content significantly worsened in the placebo group after 16 weeks. However, significant changes did not occur in the astaxanthin groups. Interleukin-1α levels in the stratum corneum significantly increased in the placebo and low-dose groups but not in the high-dose group between weeks 0 and 16. This study was performed in Japan from August to December, when changing environmental factors, such as UV and dryness, exacerbate skin deterioration. In conclusion, our study suggests that long-term prophylactic astaxanthin supplementation may inhibit age-related skin deterioration and maintain skin conditions associated with environmentally induced damage via its anti-inflammatory effect. (UMIN Clinical Trials Registry ID: UMIN000018550). |
| Databáze: | OpenAIRE |
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