Development of Chemosensitivity in Neurons from the Nucleus Tractus Solitarii (NTS) of Neonatal Rats
| Autor: | Robert W. Putnam, Nick A. Ritucci, Jay B. Dean, Susan C. Conrad, Nicole L. Nichols |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Patch-Clamp Techniques Physiology Carbenoxolone Neonatal age Biology In Vitro Techniques Article Membrane Potentials Hypercapnia Rats Sprague-Dawley Internal medicine medicine Solitary Nucleus Animals Drug Interactions Patch clamp Analysis of Variance General Neuroscience Solitary nucleus Gap junction Age Factors Carbon Dioxide Respiratory Center Electric Stimulation Chemoreceptor Cells Rats Endocrinology medicine.anatomical_structure Animals Newborn nervous system Anesthesia Neuron medicine.symptom Nucleus medicine.drug circulatory and respiratory physiology |
| Popis: | We studied the development of chemosensitivity during the neonatal period in rat nucleus tractus solitarii (NTS) neurons. We determined the percentage of neurons activated by hypercapnia (15% CO(2)) and assessed the magnitude of the response by calculating the chemosensitivity index (CI). There were no differences in the percentage of neurons that were inhibited (9%) or activated (44.8%) by hypercapnia or in the magnitude of the activated response (CI 164+/-4.9%) in NTS neurons from neonatal rats of all ages. To assess the degree of intrinsic chemosensitivity in these neurons we used chemical synaptic block medium and the gap junction blocker carbenoxolone. Chemical synaptic block medium slightly decreased basal firing rate but did not affect the percentage of NTS neurons that responded to hypercapnia at any neonatal age. However, in neonates aged |
| Databáze: | OpenAIRE |
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